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Simple concentration gradients are differential concentrations of a substance across a space or a membrane, but in living systems, gradients are more complex. Because ions move into and out of cells and because cells contain proteins that do not move across the membrane and are mostly negatively charged, there is also an electrical gradient, a difference of charge, across the plasma membrane. The interior of living cells is electrically negative with respect to the extracellular fluid in which they are bathed. At the same time, cells have higher concentrations of potassium (K + ) and lower concentrations of sodium (Na + ) than does the extracellular fluid, too much clenbuterol.
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